Back
Menu
Menu

15 Night Grand Ohio River and Land Tour

From St Louis to Pittsburgh

American Melody

American Cruise Lines
4 Stars
  • Cruise #: 14331815
  • Departs: Fri, Jul 2, 2027
  • Returns: Sat, Jul 17, 2027
    Track this Cruise and Get Price Alerts.
    Balcony
    Call to Book1-800-543-1915
    Suite
    Call to Book1-800-543-1915
    *Prices are per person based on double occupancy
    Includes taxes & fees
    Tap the "Request A Quote" button to get a quote include unadvertised prices including Senior, Military and Resident promotions.
    Request A Quote

    Itinerary Summary

    Day by Day Details

    Land Segment of Itinerary

    Friday - Jul 2, 2027
    Day
    1
    St Louis, United States
    • St Louis, United States
    Enjoy a relaxing hotel stay and explore the city at your leisure before embarking on your cruise. Take in the striking skyline as it unfolds along the river, crowned by the iconic Gateway Arch, a defining landmark of one of the Midwest's most celebrated cities, where the Mississippi and Missouri rivers converge. Visit Gateway Arch National Park, home to the Arch which stands as a symbol of the nation's westward expansion. Discover downtown St. Louis, taking in the riverfront, Citygarden, Soulard, Lafayette Square, and Forest Park, or visit the renowned Anheuser-Busch (Budweiser) brewery to see the legendary Clydesdales. ...
    Read More

    Land Segment of Itinerary

    Saturday - Jul 3, 2027
    Day
    2
    St Louis, United States
    • St Louis, United States

    Cruise Segment of Itinerary

    Day 2 - Saturday - Jul 3, 2027
    Day
    2
    Cruise Begins
    • Cruise Begins
    • St Louis, United States
    • Cruising the Mississippi River, United States
    Board the ship and begin your travels along the Mississippi River toward Hannibal. From the sun deck, take in small towns and agricultural stretches that reflect the working landscape of this region. Take time to get comfortable in your stateroom and admire the scenery from your private balcony. Or participate in onboard enrichment activities that highlight the culture and history of the river. Don't miss cocktail hour, a chance to meet fellow travelers, before enjoying dinner inspired by local flavors. ...
    Read More
    Sunday - Jul 4, 2027
    Day
    3
    Paducah, United States
    • Paducah, United States
    At the meeting point of the Tennessee River and the Ohio River lies Paducah, a designated UNESCO Creative City of Crafts and Folk Art. With the guidance of a seasoned local expert, delve into its layered history and evolving creative identity. Explore the city's Wall-to-Wall Floodwall Murals, a public art installation featuring more than 50 large-scale works depicting Native American heritage, pivotal Civil War moments, and local landmarks. Continue to the LowerTown Arts District, a 25-square-block neighborhood where restored buildings now house studios, galleries, and a thriving community of working artists. Among Paducah's cultural highlights, the National Quilt Museum stands out as a nationally recognized institution that attracts textile artists and design enthusiasts from across the country. Its exhibits celebrate the artistry, innovation, and cultural depth of quilting. ...
    Read More
    Monday - Jul 5, 2027
    Day
    4
    • Cruising the Ohio River, United States
    As you cruise the Ohio River, keep watch for white-tailed deer, red foxes, cottontail rabbits, and other wildlife. From the water's edge to forests and wetlands, the river supports a remarkable variety of plant and animal life. Onboard enrichment offers a closer look at the Ohio River's ecology, including conservation efforts that help protect its habitats and its importance to migratory bird populations. Learn how seasonal changes and waterways support wildlife throughout the region. With every passing mile, discover the living countryside surrounding the river and gain a deeper appreciation for the delicate ecosystem that makes this scenic journey so captivating. ...
    Read More
    Tuesday - Jul 6, 2027
    Day
    5
    • Henderson, United States
    Discover the rich character of Henderson and Evansville, two distinctive Ohio River communities. In relaxed Henderson, uncover the legacy of naturalist and artist John James Audubon, who found creative inspiration here in the early 1800s while creating masterpieces for Birds of America. At the Audubon Museum and Nature Center, a park guide brings the artist's life and work into focus. From there, take time to explore the museum's galleries, wildlife observation room, theater, and Discovery & Learning Center at your own pace. Just downriver, Evansville blends contemporary energy with historic charm. Visit the Evansville Wartime Museum, an excursion honoring the region's armed forces and hometown heroes whose manufacturing contributions supported the Allied effort during World War II. Then, step inside the Reitz Home Museum for an elegant Victorian Tea Party while learning about its remarkable 1871 French Second Empire architecture. ...
    Read More
    Wednesday - Jul 7, 2027
    Day
    6
    • Cruising the Ohio River, United States
    The grand Ohio River invites you to embrace a slower, more immersive way of experiencing America's heartland. Settle into the rhythm of the river as you take in stunning views and quaint riverside towns from the top deck. Savor the natural beauty of the Ohio River Valley and watch each changing vista unfold along the way. Enrich your journey with onboard activities, from engaging presentations to lively discussions, that add depth and context to the landscapes around you. Sail through a region steeped in history, where every mile reveals a new chapter in the story of the Ohio River. ...
    Read More
    Thursday - Jul 8, 2027
    Day
    7
    Louisville, United States
    • Louisville, United States
    Louisville, a vibrant waterfront city nestled along the Ohio River, has played an important role in America's history. For generations, the river shaped Louisville's destiny, as boats were forced to stop where the Ohio's rocky rapids interrupted their journey. Step into the world of horseracing at the legendary Churchill Downs, home to the Kentucky Derby, the oldest continuously held horse race in the nation. For a slice of Americana, visit the Louisville Slugger Museum & Factory, where the iconic baseball bats are crafted. No visit to Louisville would be complete without experiencing its famed bourbon heritage. Explore a local distillery as the aroma of aging spirits fills the air. Sip the refined flavors of Kentucky bourbons, each taste telling a story of craftsmanship and Bluegrass country. ...
    Read More
    Friday - Jul 9, 2027
    Day
    8
    • Madison, United States
    A quaint town located on the banks of the Ohio River, Madison is one of the oldest and most captivating cities in the state, known for its well-preserved 19th-century architecture. Listed on the National Register of Historic Places, Madison features over 130 preserved buildings that showcase a mix of Greek Revival, Victorian, and Federal styles. Experience Madison aboard a vintage-style trolley, enjoying fascinating stories, local landmarks, and a special visit to one of the town's treasured churches. Later, discover Lanier, the "Crown Jewel" of Madison's Historic District. Explore this 1844 Greek Revival mansion, learn about James F. D. Lanier's legacy, and be treated to refreshing lemonade on the home's grand porch or expansive lawn. In the afternoon, step aboard a jet boat for an adventure on the Ohio River. As you cruise this picturesque waterway, the captain and crew will share local insights and help you spot wildlife along the way. ...
    Read More
    Saturday - Jul 10, 2027
    Day
    9
    Cincinnati, United States
    • Cincinnati, United States
    The dramatic bridges spanning the Ohio River provide a striking welcome to Cincinnati, a vibrant city with a storied past as an early shipbuilding and shipping metropolis. Known as the "Queen City", Cincinnati blends old-world allure, cultural attractions, and a proud sporting legacy. Experience the excitement of America's favorite pastime with a private behind-the-scenes look at the Great American Ball Park, home of the Cincinnati Reds. Explore the clubs, seating bowl, dugouts, and more before visiting the Reds Hall of Fame and Museum to celebrate the legends of the game. Delve into the history of the National Underground Railroad Freedom Center, where powerful exhibits illustrate the stories of courage, resilience, and determination that helped enslaved individuals seek freedom. ...
    Read More
    Sunday - Jul 11, 2027
    Day
    10
    • River Cruising
    Today is all about carefree enjoyment as you settle into the relaxed rhythm of river cruising. Make the day your own while deepening your appreciation for the history, character, and hospitality that define the region. From expansive lounges to the sun deck, find a favorite spot to relax with a good book, take in the breeze, or simply watch the river go by. Throughout the day, savor an array of onboard delights, from chef-inspired regional cuisine and signature cocktails to freshly baked daily treats. Engage with educational presentations that bring the river's stories and surroundings to life, enjoy live entertainment, and share memorable moments with fellow travelers. ...
    Read More
    Monday - Jul 12, 2027
    Day
    11
    • Maysville, United States
    Discover the small-town charm and rich history of Maysville, one of the Ohio River's most historically significant river towns. A narrated exploration reveals its connections to early American commerce, westward expansion, and the Underground Railroad. Begin at the Kentucky Gateway Museum Center, where award-winning dioramas and fascinating artifacts bring the stories of explorers, artists, and movie stars to life. Then visit the Russell Theatre, a beloved Maysville landmark opened in 1930 by businessman Colonel J. Barbour Russell. Learn about its connection to Maysville native Rosemary Clooney, whose film The Stars Are Singing premiered here in 1953, and admire memorabilia celebrating that memorable occasion. Saved from demolition by volunteers, the beautifully restored theater remains a cherished part of Maysville's heritage and is listed on the National Register of Historic Places. ...
    Read More
    Tuesday - Jul 13, 2027
    Day
    12
    • Cruising the Ohio River, United States
    Cruise at a relaxed pace along this scenic riverside route. From observation lounges, open-air decks, or private balconies, take in the changing landscapes and enjoy a peaceful escape from the bustle. As you sail, onboard enrichment introduces the Ohio River's important role in early settlement, river commerce, and the communities that flourished on its banks. Approaching Marietta, the region's rich heritage comes into view. One of the oldest settlements in the Northwest Territory, Marietta welcomes guests with well-preserved architecture, a storied riverfront, and a warm small-town atmosphere ...
    Read More
    Wednesday - Jul 14, 2027
    Day
    13
    • Marietta, United States
    Nestled at the confluence of the Muskingum and Ohio rivers, Marietta offers a fascinating glimpse into America's early days. Founded in 1788 as the first permanent settlement in the Northwest Territory, this enchanting river town preserves its pioneering spirit through its historic architecture and a wealth of notable landmarks. Guests can delve into Marietta's remarkable past on a guided Earthworks Walking Exploration, viewing ancient Native American earthworks and learning about the mysteries, discoveries, and ongoing research surrounding these extraordinary sites. The journey continues with a visit to the Castle Historic House Museum, a beautifully preserved 1855 Gothic Revival home steeped in local history. Step inside to discover fascinating stories from Marietta's past while admiring its distinctive brickwork, elegant turret, ornate interiors, intricate woodwork, and carefully preserved period furnishings. ...
    Read More
    Thursday - Jul 15, 2027
    Day
    14
    • Cruising the Ohio River, United States
    Cruise along the Ohio River toward Pittsburgh, enjoying a leisurely journey through one of America's most iconic waterways. As you make your way toward this historic river city, watch the scenery unfold, from gentle hills and wooded banks to charming riverfront communities and scenic valleys. Take in the panoramic vistas from the top deck or retreat to your private balcony for a peaceful moment surrounded by river views. Throughout the day, join in onboard activities such as trivia sessions in the lounge, or simply relax and enjoy the unhurried rhythm of river cruising. As you approach Pittsburgh, appreciate the significance of a city shaped by the confluence of three rivers and its important role in American industry, commerce, and westward expansion. ...
    Read More
    Friday - Jul 16, 2027
    Day
    15
    Pittsburgh, United States
    • Pittsburgh, United States
    Pittsburgh offers a fascinating finale to your Ohio River journey. Once a powerhouse of steel manufacturing and a vital center for national and international commerce, the city grew into a thriving 18th- and 19th-century industrial hub. Today, the "Steel City" has transformed into an established destination known for its technology, culture, universities, and world-class medical institutions. Discover Pittsburgh's remarkable evolution on a locally guided experience through some of the neighborhoods and popular sights that define the city's character. Explore the South Side, once home to bustling steel mills and now a district blending history and modern attractions. Travel through the elegant streets of Millionaires' Row, lined with grand mansions reflecting Pittsburgh's prosperous industrial era, before visiting the Downtown Golden Triangle, the heart of the city where three rivers meet. Continue to the North Side, home to celebrated cultural and sporting landmarks, before ascending Mount Washington for breathtaking panoramic views of Pittsburgh's dramatic skyline and riverfront. ...
    Read More
    Saturday - Jul 17, 2027
    Day
    16
    Pittsburgh, United States
    • Pittsburgh, United States
    After breakfast onboard, begin your journey home with memories of welcoming river towns, idyllic scenery, and unforgettable moments along the Ohio River. Reflect on the connections made through shared excursions, onboard activities, and time spent with fellow guests and crew.


    Get FREE Price Alerts

    Subscribe to our weekly cruise deals email and enjoy FREE price change alerts and updates for this cruise and others like it.

    Track this Cruise

    We promise to protect your privacy and personal data. You can review our privacy policy here.

    Complete the form below and we will send this cruise and a message to your friends on your behalf.

    Enter up to 5 emails separated by commas:

    Your First Name

    Your Last Name

    Your Email Address:

    Optional Message to Your Friend(s):

    Send Email

    Please enter your email address to Add to Favorites. You can then access this cruise from other devices.


    Email Address:

    Save to Favorites

    This cruise line does not offer live online pricing. Please complete the form below for a quote on this cruise or call for rates.


    How many are traveling
    Adults (Age 18 and over)
    Kids (6 months to 17 years)
    First NameLast NameState of Residence

    Phone NumberEmail AddressAny special request or comments?

    Submit Request >